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Sacubitril valsartan and ACE inhibitor — GPhC CRA MCQ

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HardCardiovascular TherapeuticsSacubitril valsartan and ACE inhibitorGPhC CRA

A discharge prescription includes sacubitril/valsartan starting tonight. The inpatient drug chart shows ramipril was given this morning. What is the most appropriate action?

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Correct answer: E — Query the prescription because a washout period is needed after ACE inhibitor use

Sacubitril/valsartan must not be started too soon after an ACE inhibitor because of angioedema risk. A washout period is required before initiation. The discharge prescription should be clarified before supply.

Reference: BNF; NICE CKS