Atorvastatin-amlodipine interaction — GPhC CRA MCQ

Correct answer: C — Amlodipine can increase atorvastatin levels via CYP3A4 inhibition, though the interaction is generally mild and does not usually require dose adjustment at standard amlodipine doses

Amlodipine is a weak inhibitor of CYP3A4 and can modestly increase atorvastatin plasma concentrations. However, this interaction is generally not clinically significant at usual therapeutic doses and does not typically require dose adjustment. The BNF notes this interaction but it is classified as less severe than with stronger CYP3A4 inhibitors. The prescriber has likely considered this, but the patient should be advised to report any unexplained muscle pain.

Reference: BNF Drug Interactions