Heart failure optimisation — GPhC CRA MCQ
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Correct answer: C — A mineralocorticoid-receptor antagonist plus an SGLT2 inhibitor
NICE updated NG106 in 2025 to consider an MRA and SGLT2 inhibitor for HFpEF. Diuretics still manage congestion and comorbidities require treatment, but neither replaces the disease-modifying combination. Renal function, potassium, blood pressure and adverse effects guide introduction.
Reference: NICE NG106: chronic heart failure — recommendations: https://www.nice.org.uk/guidance/ng106/chapter/recommendations