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Statin rhabdomyolysis — GPhC CRA MCQ

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EasyCardiovascular TherapeuticsStatin rhabdomyolysisGPhC CRA

A 52-year-old man taking atorvastatin 40 mg daily presents to the pharmacy complaining of unexplained muscle pain and weakness that has developed over the past two weeks. His urine has appeared darker than usual. What is the most appropriate action?

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Correct answer: A — Refer him urgently to the GP for creatine kinase measurement and assessment for rhabdomyolysis

Unexplained muscle pain, tenderness, or weakness accompanied by dark urine (myoglobinuria) is a red flag for rhabdomyolysis, a serious and potentially life-threatening complication of statin therapy. The patient requires urgent referral for creatine kinase (CK) measurement and renal function assessment. A CK level more than 10 times the upper limit of normal confirms rhabdomyolysis. The pharmacist should not advise stopping or switching medication without medical assessment.

Reference: BNF Statins; MHRA Drug Safety Update; NICE CKS Statins