Paracetamol overdose risk and opioid tolerance — GPhC CRA MCQ
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Correct answer: A — Six grams daily; stop dosing and obtain urgent toxicology advice
Twelve tablets each containing 500 mg provide 6 g paracetamol daily. Repeated supratherapeutic ingestion can cause hepatotoxicity even before symptoms appear. Further paracetamol should be withheld and urgent clinical or toxicology assessment arranged; opioid tolerance also needs review.
Reference: BNF: paracetamol: https://bnf.nice.org.uk/drugs/paracetamol/