DAPT duration post-MI — GPhC CRA MCQ
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Correct answer: E — Do not use sildenafil while nitrate therapy may be needed
Phosphodiesterase-5 inhibitors can markedly potentiate the hypotensive effect of nitrates. Sildenafil must not be used while regular or rescue nitrate treatment may be required; an arbitrary dose interval or dose reduction does not make the combination safe. The patient needs prescriber review of erectile-dysfunction and anti-anginal management rather than over-the-counter supply.
Reference: https://www.pharmacyregulation.org/students-and-trainees/pharmacist-education-and-training/registration-assessment