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Carbimazole agranulocytosis warning — GPhC CRA MCQ

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EasyAdverse Drug ReactionsCarbimazole agranulocytosis warningGPhC CRA

A 50-year-old woman with newly diagnosed Graves' disease presents with a prescription for carbimazole 20 mg once daily. What is the most important safety advice to give her?

Educational content. Not a substitute for clinical judgement or local policy.

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Correct answer: E — She should seek immediate medical attention if she develops a sore throat, fever, or mouth ulcers as these may indicate agranulocytosis

Carbimazole can cause agranulocytosis, a rare but serious adverse effect. Patients must be warned to report symptoms of infection immediately, particularly sore throat, mouth ulcers, bruising, or fever. A full blood count should be performed if these symptoms develop. The MHRA has issued specific guidance that all patients starting carbimazole must receive a patient information card and be told about this risk.

Reference: BNF; MHRA Drug Safety Update