skip to main content

Antipsychotics in dementia risk — GPhC CRA MCQ

Instant feedback + full explanation. One question, done properly.

EasyCNS TherapeuticsAntipsychotics in dementia riskGPhC CRA

A 78-year-old man with dementia is prescribed haloperidol 0.5 mg twice daily for persistent agitation. His daughter asks the pharmacist about the risks. Which is the most important safety concern to discuss?

Educational content. Not a substitute for clinical judgement or local policy.

Reveal the answer and explanation

Correct answer: E — Antipsychotics in dementia are associated with an increased risk of stroke and mortality

Antipsychotic use in elderly patients with dementia is associated with a significant increase in the risk of stroke and all-cause mortality. The MHRA has issued warnings about this, and NICE dementia guidelines emphasise that antipsychotics should only be used when non-pharmacological approaches have failed and there is severe distress or risk of harm. Treatment should be at the lowest effective dose for the shortest time, with regular review.

Reference: MHRA Drug Safety Update; NICE NG97 Dementia; BNF