skip to main content

Constipation first-line treatment — GPhC CRA MCQ

Instant feedback + full explanation. One question, done properly.

EasyGI TherapeuticsConstipation first-line treatmentGPhC CRA

A 28-year-old man presents asking for advice on his constipation. He has been constipated for four days and has no other symptoms. He takes no regular medication and has no medical history. He has tried increasing his fluid and fibre intake without improvement. What is the most appropriate first-line laxative to recommend?

Educational content. Not a substitute for clinical judgement or local policy.

Reveal the answer and explanation

Correct answer: A — Macrogol (Movicol) one sachet three times daily

NICE CKS recommends macrogol (polyethylene glycol) as the first-line osmotic laxative for constipation in adults. It is well-tolerated and effective. While senna (a stimulant) and lactulose (an osmotic) are also used, macrogol is preferred as it has better evidence for efficacy and tolerability. Bisacodyl suppositories are generally reserved for more refractory cases or when oral administration is not possible.

Reference: NICE CKS Constipation; BNF