A 70-year-old woman in a care home is prescribed a 7-day course of co-amoxiclav for a lower respiratory tract infection. She is also taking warfarin

Question

A 70-year-old woman in a care home is prescribed a 7-day course of co-amoxiclav for a lower respiratory tract infection. She is also taking warfarin for atrial fibrillation. Her INR has been stable at 2.8 for 3 months. What monitoring is required?

Accepted Answer

Recheck INR within 3-5 days of starting the antibiotic

Answer

Reduce the warfarin dose by 50% for the duration of the course

Answer

Switch warfarin to a DOAC for the duration of the antibiotic course

Answer

No additional monitoring is required as co-amoxiclav does not interact with warfarin

Answer

Check renal function before dispensing the co-amoxiclav

Antibiotic-warfarin interaction — GPhC CRA MCQ

A 70-year-old woman in a care home is prescribed a 7-day course of co-amoxiclav for a lower respiratory tract infection. She is also taking warfarin for atrial fibrillation. Her INR has been stable at 2.8 for 3 months. What monitoring is required?