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Parkinson's medication withdrawal — GPhC CRA MCQ

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HardCNS TherapeuticsParkinson's medication withdrawalGPhC CRA

A 70-year-old woman with Parkinson's disease is admitted to hospital and her medications have been temporarily withheld due to nil by mouth status for a procedure. Her family contacts the pharmacy concerned that she has become increasingly rigid and confused. What is the most appropriate advice?

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Correct answer: A — Advise the family to contact the ward urgently as abrupt withdrawal of Parkinson's medication can cause neuroleptic malignant-like syndrome

Abrupt withdrawal of dopaminergic medication in Parkinson's disease can cause a potentially fatal neuroleptic malignant-like syndrome characterised by hyperthermia, rigidity, autonomic dysfunction, and altered consciousness. NICE emphasises that Parkinson's medications should never be stopped abruptly. The ward should be contacted urgently to arrange alternative routes of administration (e.g. rotigotine transdermal patch, dispersible formulations) or to reinstate oral medication as soon as possible.

Reference: NICE NG71 Parkinson's Disease; BNF