skip to main content

Sertraline in breastfeeding — GPhC CRA MCQ

Instant feedback + full explanation. One question, done properly.

ModerateCNS TherapeuticsSertraline in breastfeedingGPhC CRA

A 35-year-old woman is prescribed sertraline 50 mg daily for moderate depression. She is currently breastfeeding a 3-month-old infant. She asks the pharmacist if sertraline is safe while breastfeeding. What is the most appropriate advice?

Educational content. Not a substitute for clinical judgement or local policy.

Reveal the answer and explanation

Correct answer: C — Sertraline is one of the preferred antidepressants in breastfeeding due to low levels in breast milk

Sertraline is considered one of the preferred SSRIs for use during breastfeeding because it has low levels in breast milk and infant serum levels are generally undetectable. The Specialist Pharmacy Service and UKDILAS recommend sertraline as a first-choice SSRI in breastfeeding mothers. Fluoxetine has a longer half-life and active metabolites, making it less preferred. Stopping breastfeeding is not necessary.

Reference: BNF; SPS Medicines in Breastfeeding; NICE CG192 Antenatal/Postnatal Mental Health