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SSRI discontinuation — GPhC CRA MCQ

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EasyCNS TherapeuticsSSRI discontinuationGPhC CRA

A 33-year-old woman with depression has been stable on sertraline 100 mg once daily for two years. She presents wanting to stop the medication as she feels well. What is the most appropriate advice about discontinuation?

Educational content. Not a substitute for clinical judgement or local policy.

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Correct answer: A — She should discuss with her GP and taper the dose gradually over several weeks to months to minimise withdrawal effects

NICE recommends that antidepressant discontinuation should be gradual, with dose reductions over weeks to months depending on the individual and the duration of treatment. Abrupt cessation can cause discontinuation symptoms including dizziness, sensory disturbances, sleep disturbance, anxiety, and irritability. After two years of stable treatment, a slow taper with GP support and monitoring for relapse is the recommended approach.

Reference: BNF; NICE CKS Depression