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Dostarlimab dMMR Rectal — SCE Medical Oncology MCQ

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HardGI CancersDostarlimab dMMR RectalSCE Medical Oncology

A patient with locally advanced mismatch-repair-deficient rectal cancer has a complete clinical response after PD-1 blockade. What is the safest next management principle?

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Correct answer: D — Discuss organ preservation in an expert multidisciplinary programme with intensive surveillance

Immunotherapy can produce striking complete responses in dMMR rectal cancer, but the evidence does not justify unsupervised omission of established treatment. Organ-preserving management requires expert multidisciplinary confirmation of complete response, shared discussion of uncertainty and a rigorous endoscopic, imaging and clinical surveillance programme.

Reference: https://www.nice.org.uk/guidance/conditions-and-diseases/cancer