A patient has unresectable locally advanced cutaneous squamous-cell carcinoma. Curative radiotherapy is unsuitable because the required field would

Question

A patient has unresectable locally advanced cutaneous squamous-cell carcinoma. Curative radiotherapy is unsuitable because the required field would cause unacceptable morbidity. There is no distant disease. Which NICE-supported systemic option fits this setting?

Accepted Answer

Use cemiplimab because neither curative surgery nor curative radiotherapy is suitable

Answer

Use cemiplimab after a non-curative radiotherapy course has first been completed

Answer

Use cemiplimab after confirming a PD-L1 tumour proportion score of at least 50%

Answer

Use pembrolizumab because NICE excludes cemiplimab in non-metastatic disease

Answer

Use cetuximab because cemiplimab requires established distant metastases

Adjuvant Melanoma 1 Year — SCE Medical Oncology MCQ

A patient has unresectable locally advanced cutaneous squamous-cell carcinoma. Curative radiotherapy is unsuitable because the required field would cause unacceptable morbidity. There is no distant disease. Which NICE-supported systemic option fits this setting?