skip to main content

ToGA Gastric HER2 — SCE Medical Oncology MCQ

Instant feedback + full explanation. One question, done properly.

EasyGI CancersToGA Gastric HER2SCE Medical Oncology

A 55-year-old woman with advanced gastric cancer has HER2 IHC 2+/FISH positive. She is started on trastuzumab + chemotherapy. What landmark trial established this?

Educational content. Not a substitute for clinical judgement or local policy.

Reveal the answer and explanation

Correct answer: B — ToGA — trastuzumab + cisplatin-fluoropyrimidine significantly improved OS compared with chemotherapy alone (13.8 vs 11.1 months) in HER2-positive advanced gastric/GOJ cancer

ToGA (Bang et al Lancet 2010): first biomarker-directed therapy in gastric cancer. OS 13.8 vs 11.1 months with trastuzumab + chemo. HER2-positive (~15-20% gastric). NICE approved. HER2 testing now mandatory for all advanced gastric cancer.

Reference: ToGA Bang et al Lancet 2010; NICE; ESMO 2024 Gastric