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Ewing Sarcoma VDC-IE — SCE Medical Oncology MCQ

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ModerateSarcomaEwing Sarcoma VDC-IESCE Medical Oncology

A 55-year-old man with Ewing sarcoma (EWSR1-FLI1 fusion) of the pelvis is treated with neoadjuvant chemotherapy. What standard chemotherapy regimen is used for Ewing sarcoma?

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Correct answer: E — VDC/IE alternating (vincristine, doxorubicin, cyclophosphamide alternating with ifosfamide + etoposide) — the standard multi-agent regimen; interval-compressed (every 2 weeks with G-CSF) is preferred based on INT-0091/AEWS0031

Ewing sarcoma: VDC/IE (vincristine/doxorubicin/cyclophosphamide alternating with ifosfamide/etoposide) × 14 cycles. AEWS0031: interval-compressed (every 2 weeks) superior to standard every 3 weeks. Neoadjuvant→surgery→adjuvant. Histological response (≥90% necrosis) is prognostic.

Reference: ESMO 2024 Bone Sarcoma; AEWS0031 Womer et al JCO 2012