Opioid Neurotoxicity — SCE Medical Oncology MCQ
Instant feedback + full explanation. One question, done properly.
Educational content. Not a substitute for clinical judgement or local policy.
Reveal the answer and explanation
Correct answer: B — Opioid neurotoxicity from M3G/M6G metabolite accumulation — management is opioid ROTATION (not dose increase) to agents with fewer active metabolites (fentanyl, oxycodone)
Opioid neurotoxicity: myoclonus, allodynia, hallucinations from M3G accumulation. Risk factors: high dose, renal impairment. Rotate to fentanyl (no active metabolites) or oxycodone. Hydration also helps.
Reference: NICE CG140; Palliative Care Formulary