A 32-year-old woman with a pathogenic PTEN variant asks for annual endometrial biopsy despite having no abnormal bleeding. Which statement best

Question

A 32-year-old woman with a pathogenic PTEN variant asks for annual endometrial biopsy despite having no abnormal bleeding. Which statement best matches the European/UKCGG-hosted surveillance guideline?

Accepted Answer

Use symptom-triggered assessment; routine endometrial surveillance is not recommended outside a clinical trial

Answer

Begin annual endometrial biopsy from age 18 and continue despite repeatedly normal histological findings

Answer

Begin annual transvaginal ultrasonography from age 30 and biopsy only when endometrial thickness exceeds 4 mm

Answer

Provide population-level advice only because PTEN pathogenic variants do not increase endometrial-cancer risk

Answer

Offer risk-reducing hysterectomy before age 35 as the routine alternative to endometrial surveillance

Hyperviscosity — SCE Medical Oncology MCQ

A 32-year-old woman with a pathogenic PTEN variant asks for annual endometrial biopsy despite having no abnormal bleeding. Which statement best matches the European/UKCGG-hosted surveillance guideline?