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MRONJ Staging — SCE Medical Oncology MCQ

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ModerateImmunotherapy & Targeted TherapyMRONJ StagingSCE Medical Oncology

A 60-year-old man on cabozantinib for RCC develops MRONJ (Stage 2: exposed bone + infection). What is the AAOMS staging?

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Correct answer: C — Stage 2 — exposed bone with evidence of infection (pain, purulent drainage, fistula); Stage 1 = exposed bone without infection; Stage 3 = pathological fracture/extraoral fistula

AAOMS MRONJ: Stage 0 = no exposed bone, non-specific findings; 1 = exposed bone, asymptomatic; 2 = exposed bone + infection; 3 = fracture/extraoral fistula. Management escalates by stage.

Reference: AAOMS 2022; ESMO Supportive Care