Mesna — SCE Medical Oncology MCQ

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EasyOncological EmergenciesMesnaSCE Medical Oncology

A 62-year-old man receives high-dose cyclophosphamide. He develops haemorrhagic cystitis. What preventive agent should have been co-administered?

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Correct answer: E — Mesna — binds acrolein (urotoxic cyclophosphamide/ifosfamide metabolite) in the urinary tract preventing haemorrhagic cystitis

Mesna: free thiol binding acrolein in urinary tract. Mandatory with ifosfamide (all doses) and high-dose cyclophosphamide (conditioning). No systemic anti-tumour effect.

Reference: BNF Mesna; ESMO Supportive Care