skip to main content

Q-TWiST — SCE Medical Oncology MCQ

Instant feedback + full explanation. One question, done properly.

HardClinical Trials & StatisticsQ-TWiSTSCE Medical Oncology

In an elderly radiotherapy cohort, investigators want the 2-year absolute probability of grade 3 neuropathy. Some patients die before neuropathy and can never experience it. Which analysis should be primary for the absolute risk?

Educational content. Not a substitute for clinical judgement or local policy.

Reveal the answer and explanation

Correct answer: B — Cumulative-incidence function treating death as a competing event

Explanation lettering: D = shown as A · A = shown as B · E = shown as C · B = shown as D · C = shown as E

A is correct: death precludes neuropathy and must enter the cumulative-incidence function as a competing event. B treats death as non-informative censoring and overestimates incidence; C conditions on 2-year survival; D excludes deaths and therefore selects the analysed cohort; E estimates follow-up distribution, not neuropathy risk.

Reference: Competing risks data in clinical oncology (Journal of Clinical Medicine 2024): https://pmc.ncbi.nlm.nih.gov/articles/PMC11024219/