skip to main content

Naloxegol PAMORA — SCE Medical Oncology MCQ

Instant feedback + full explanation. One question, done properly.

ModerateSupportive & Palliative OncologyNaloxegol PAMORASCE Medical Oncology

A 65-year-old man with cancer on opioids develops OIC refractory to conventional laxatives. Naloxegol is prescribed. What is it?

Educational content. Not a substitute for clinical judgement or local policy.

Reveal the answer and explanation

Correct answer: B — An oral peripherally-acting µ-opioid receptor antagonist (PAMORA) blocking gut opioid receptors without crossing the BBB — reverses OIC without affecting central analgesia

Naloxegol is PEGylated naloxol — PEG moiety prevents BBB penetration. Blocks gut µ-receptors (reversing OIC) without affecting central analgesia. NICE recommends after conventional laxative failure.

Reference: BNF Naloxegol; NICE CG140