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Bevacizumab Nephrotic — SCE Medical Oncology MCQ

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ModerateOncological EmergenciesBevacizumab NephroticSCE Medical Oncology

A 55-year-old woman on bevacizumab develops nephrotic-range proteinuria (>3.5 g/24h). What is the management?

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Correct answer: B — Permanently discontinue bevacizumab — nephrotic-range proteinuria is a contraindication to continuing any anti-VEGF therapy

Anti-VEGF proteinuria: <1g → continue; 1-3.5g → hold, resume when <2g; >3.5g (nephrotic) → permanent discontinuation. Indicates significant glomerular endothelial damage.

Reference: BNF Bevacizumab; ESMO Supportive Care