Hypothyroidism Continue ICI — SCE Medical Oncology MCQ

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EasyMelanoma & SkinHypothyroidism Continue ICISCE Medical Oncology

A 62-year-old man with melanoma on adjuvant nivolumab develops grade 2 hypothyroidism. Should nivolumab be continued?

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Correct answer: A — Continue nivolumab AND start levothyroxine — hypothyroidism managed with replacement does NOT require ICI cessation at any grade

ICI-induced hypothyroidism: thyroid is already destroyed (irreversible), levothyroxine replacement fully corrects. ICI can continue at any hypothyroidism grade. Same applies to T1DM on insulin.

Reference: https://www.nice.org.uk/guidance/conditions-and-diseases/cancer