POLE Endometrial — SCE Medical Oncology MCQ
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Correct answer: B — Suspend trastuzumab and repeat LVEF assessment in about 3 weeks
The fall is 13 percentage points and the new LVEF is below 50%, meeting both SmPC conditions for suspension and reassessment after about three weeks. Continuing or dose-reducing ignores the threshold; permanent cessation is considered if function does not improve, declines further, or symptomatic heart failure develops, not automatically after this first result.
Reference: Herceptin 150 mg UK SmPC. https://www.medicines.org.uk/emc/product/3856/smpc