skip to main content

NET G3 vs NEC G3 — SCE Medical Oncology MCQ

Instant feedback + full explanation. One question, done properly.

HardGI CancersNET G3 vs NEC G3SCE Medical Oncology

A pancreatic neuroendocrine neoplasm has organoid architecture, salt-and-pepper chromatin, Ki-67 35%, strong SSTR2 expression, loss of ATRX and retained Rb with no aberrant p53 pattern. Which classification is best supported?

Educational content. Not a substitute for clinical judgement or local policy.

Reveal the answer and explanation

Correct answer: C — Well-differentiated neuroendocrine tumour, grade 3

Explanation lettering: C = shown as A · D = shown as C · A = shown as D

D is correct: differentiation is morphological, and ATRX loss plus SSTR2 expression supports pancreatic NET biology despite grade 3 proliferation. A incorrectly uses Ki-67 alone to call large-cell NEC; B wrongly treats all grade-3 neoplasms as small-cell NEC; C conflicts with classic NET morphology; E requires a substantial separate non-neuroendocrine malignant component not described.

Reference: ENETS 2023 guidance for digestive neuroendocrine carcinoma (Published 2023): https://onlinelibrary.wiley.com/doi/10.1111/jne.13249