Six days after intensive chemotherapy, a patient presents with temperature 38.6°C, rigors, blood pressure 94/58 mmHg and neutrophils 0.2 × 10^9/L.

Question

Six days after intensive chemotherapy, a patient presents with temperature 38.6°C, rigors, blood pressure 94/58 mmHg and neutrophils 0.2 × 10^9/L. There is no severe beta-lactam allergy and no local resistance alert. Which initial empiric antibiotic strategy follows NICE CG151?

Accepted Answer

Intravenous piperacillin-tazobactam monotherapy without routine aminoglycoside addition

Answer

Gentamicin monotherapy until cultures identify an organism

Answer

Oral ciprofloxacin and discharge before risk assessment

Answer

Vancomycin plus gentamicin routinely because a central line is present

Answer

Cefalexin monotherapy because the source is not yet known

LMS vs Leiomyoma — SCE Medical Oncology MCQ

Six days after intensive chemotherapy, a patient presents with temperature 38.6°C, rigors, blood pressure 94/58 mmHg and neutrophils 0.2 × 10^9/L. There is no severe beta-lactam allergy and no local resistance alert. Which initial empiric antibiotic strategy follows NICE CG151?