Before cabozantinib is started for metastatic cancer, which gastrointestinal history should create the greatest concern for subsequent perforation or

Question

Before cabozantinib is started for metastatic cancer, which gastrointestinal history should create the greatest concern for subsequent perforation or fistula and prompt especially close risk assessment?

Accepted Answer

Peritoneal carcinomatosis with bowel-wall tumour infiltration and a poorly healed prior bowel anastomosis

Answer

Remote cholecystectomy with complete wound healing and no residual biliary or intestinal disease

Answer

Stable lactose intolerance controlled by diet with normal bowel imaging and no inflammatory disease

Answer

Previous appendicectomy in childhood with complete healing and no current intra-abdominal malignancy

Answer

Uncomplicated reflux disease controlled with a proton-pump inhibitor and no prior abdominal operation

Anti-VEGF Perforation Stent — SCE Medical Oncology MCQ

Before cabozantinib is started for metastatic cancer, which gastrointestinal history should create the greatest concern for subsequent perforation or fistula and prompt especially close risk assessment?