Twelve years after pelvic radiotherapy, a woman develops a histologically distinct sarcoma centred within the previous high-dose field. There was no

Question

Twelve years after pelvic radiotherapy, a woman develops a histologically distinct sarcoma centred within the previous high-dose field. There was no lesion there before radiotherapy. Which interpretation and planning step is most defensible?

Accepted Answer

The combined features support a radiation-associated second primary; retrieve the old plan before specialist treatment planning

Answer

The field location establishes radiation causation; begin re-irradiation before confirming histological independence

Answer

The absence of an earlier mass establishes a radiation-induced tumour; management is identical to an unirradiated sarcoma

Answer

The distinct histology establishes a sporadic tumour; prior dose distribution is irrelevant to surgery and radiotherapy

Answer

The long latency establishes recurrent cervical cancer; use the original histology and stage to select systemic therapy

Radiation-induced Second Cancer — SCE Medical Oncology MCQ

Twelve years after pelvic radiotherapy, a woman develops a histologically distinct sarcoma centred within the previous high-dose field. There was no lesion there before radiotherapy. Which interpretation and planning step is most defensible?