Capecitabine monotherapy is planned at the standard 1250 mg/m² twice-daily starting schedule. Baseline Cockcroft-Gault creatinine clearance is 42

Question

Capecitabine monotherapy is planned at the standard 1250 mg/m² twice-daily starting schedule. Baseline Cockcroft-Gault creatinine clearance is 42 mL/min and there is no complete DPD deficiency. What initial capecitabine adjustment does the UK SmPC specify?

Accepted Answer

Start at seventy-five percent of the 1250 mg/m² dose and monitor closely

Answer

Start at fifty percent of the 1250 mg/m² dose and never re-escalate

Answer

Start the full 1250 mg/m² dose and reduce only after grade 3 toxicity

Answer

Substitute full-dose infusional fluorouracil because renal function does not affect its metabolites

Answer

Withhold capecitabine because any creatinine clearance below 50 mL/min is contraindicated

Capecitabine Ileostomy — SCE Medical Oncology MCQ

Capecitabine monotherapy is planned at the standard 1250 mg/m² twice-daily starting schedule. Baseline Cockcroft-Gault creatinine clearance is 42 mL/min and there is no complete DPD deficiency. What initial capecitabine adjustment does the UK SmPC specify?