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irAE Optic Neuropathy — SCE Medical Oncology MCQ

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HardOncological EmergenciesirAE Optic NeuropathySCE Medical Oncology

A trial reports an overall-survival hazard ratio of 0.65 (95% CI 0.50–0.85) for a new treatment versus control. Which interpretation is correct?

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Correct answer: B — A 35% lower instantaneous hazard; the interval excludes 1

A hazard ratio of 0.65 estimates a 35% lower instantaneous event hazard in the treatment group under the proportional-hazards interpretation. Because the confidence interval excludes 1, the result is statistically significant at the conventional level. It does not directly state an absolute risk reduction, survival probability or proportional increase in median survival.

Reference: https://www.nice.org.uk/guidance/conditions-and-diseases/cancer