A man has newly diagnosed metastatic hormone-sensitive prostate cancer. Docetaxel is unsuitable because of severe neuropathy. Darolutamide and

Question

A man has newly diagnosed metastatic hormone-sensitive prostate cancer. Docetaxel is unsuitable because of severe neuropathy. Darolutamide and apalutamide are both clinically suitable and locally available. Which statement best reflects NICE TA1109?

Accepted Answer

Use darolutamide plus ADT, choosing the cheaper suitable option versus apalutamide

Answer

Add darolutamide to docetaxel after using dose reduction for the neuropathy

Answer

Continue ADT alone because docetaxel unsuitability also excludes androgen-receptor inhibition

Answer

Use darolutamide only after previous docetaxel and subsequent development of castration-resistant disease

Answer

Use darolutamide rather than apalutamide because neuropathy excludes the latter drug

Darolutamide CNS Profile — SCE Medical Oncology MCQ

A man has newly diagnosed metastatic hormone-sensitive prostate cancer. Docetaxel is unsuitable because of severe neuropathy. Darolutamide and apalutamide are both clinically suitable and locally available. Which statement best reflects NICE TA1109?