skip to main content

Endometrial SLN Mapping — SCE Medical Oncology MCQ

Instant feedback + full explanation. One question, done properly.

HardGynaecological CancersEndometrial SLN MappingSCE Medical Oncology

A 62 kg woman with newly diagnosed advanced high-grade serous ovarian cancer has responded to platinum treatment. Baseline platelets are 182,000/microlitre. If first-line niraparib maintenance is chosen, what starting dose does the UK SmPC specify?

Educational content. Not a substitute for clinical judgement or local policy.

Reveal the answer and explanation

Correct answer: E — Use 200 mg once daily because both weight and platelet thresholds must be met for 300 mg

First-line niraparib uses an individualised starting dose: 300 mg daily only when both weight is at least 77 kg and baseline platelets at least 150,000/microlitre; otherwise it is 200 mg daily. This patient meets the platelet but not the weight criterion. The criteria are conjunctive, not alternatives.

Reference: Zejula 100 mg UK SmPC. https://www.medicines.org.uk/emc/product/14671/smpc