A dialysis patient with bone metastases is to start denosumab 120 mg. Corrected calcium is normal after replacement. Which plan reflects the UK SmPC?

Question

Accepted Answer

Use the 120 mg schedule unchanged, with calcium and vitamin-D supplementation plus intensified calcium monitoring

Answer

Reduce to 60 mg every 4 weeks, with calcium monitoring at the same frequency used for normal renal function

Answer

Use the 120 mg schedule unchanged, but omit calcium supplementation because dialysis increases vascular-calcification risk

Answer

Defer denosumab until dialysis is discontinued, even when hypocalcaemia has been corrected and monitoring is available

Answer

Replace denosumab with renally adjusted zoledronic acid, monitoring calcium only when neuromuscular symptoms occur

Endometrial NSMP — SCE Medical Oncology MCQ