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ADT Hot Flushes — SCE Medical Oncology MCQ

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HardUrological CancersADT Hot FlushesSCE Medical Oncology

A man with mCRPC is stable on abiraterone plus prednisolone and develops symptomatic bone-predominant progression without visceral metastases. Radium-223 is proposed while abiraterone is continued. Which is the most important prescribing response?

Educational content. Not a substitute for clinical judgement or local policy.

Reveal the answer and explanation

Correct answer: E — Do not combine them: abiraterone plus prednisone/prednisolone is contraindicated with radium-223

Explanation lettering: B = shown as A · A = shown as B

E is correct under the UK abiraterone SmPC. A does not remove the contraindication; B is not a validated workaround; C confuses radium-223 disease-site eligibility with drug-combination safety; D removes required corticosteroid cover while retaining the contraindicated abiraterone combination.

Reference: Abiraterone UK summary of product characteristics (Current UK SmPC, accessed August 2026): https://www.medicines.org.uk/emc/product/15402/smpc