A 67-year-old has a 9 mm grade 2, ER-positive, HER2-negative, node-negative invasive breast cancer excised with clear margins and agrees to at least

Question

A 67-year-old has a 9 mm grade 2, ER-positive, HER2-negative, node-negative invasive breast cancer excised with clear margins and agrees to at least five years of endocrine therapy. Which radiotherapy discussion reflects NICE guidance?

Accepted Answer

Consider omission after explaining about 5% versus 1% five-year local recurrence and unchanged 10-year survival

Answer

Omit radiotherapy only if the tumour is HER2 positive and endocrine therapy is declined

Answer

Replace radiotherapy with adjuvant chemotherapy because both provide equivalent local control

Answer

Omit radiotherapy and endocrine therapy together because their local-control effects are interchangeable

Answer

Recommend mandatory radiotherapy because omission increases 10-year all-cause mortality despite endocrine therapy

Screen-detected Prognosis — SCE Medical Oncology MCQ

A 67-year-old has a 9 mm grade 2, ER-positive, HER2-negative, node-negative invasive breast cancer excised with clear margins and agrees to at least five years of endocrine therapy. Which radiotherapy discussion reflects NICE guidance?