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Photobiomodulation Mucositis — SCE Medical Oncology MCQ

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ModerateSupportive & Palliative OncologyPhotobiomodulation MucositisSCE Medical Oncology

A 55-year-old woman with cancer develops radiation-induced mucositis after head and neck radiotherapy. She is prescribed low-level laser therapy (photobiomodulation). What is the evidence for this intervention?

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Correct answer: Clow-level laser therapy for prevention and treatment of oral mucositis from radiotherapy ± chemotherapy for head and neck cancer

Low-level laser therapy (LLLT/photobiomodulation) has strong evidence from multiple RCTs and meta-analyses for preventing and treating oral mucositis from head and neck RT ± chemotherapy. It reduces mucositis severity, pain and functional impact. ESMO/MASCC 2024 guidelines give it the strongest recommendation grade for mucositis prevention. The mechanism involves anti-inflammatory and wound-healing promotion at the cellular level. It requires specialised equipment and trained staff, limiting availability.

Reference: https://www.nice.org.uk/guidance/conditions-and-diseases/cancer