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Mesothelioma Maintenance — SCE Medical Oncology MCQ

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ModerateLung CancerMesothelioma MaintenanceSCE Medical Oncology

A 70-year-old man with mesothelioma completes 4 cycles of nivolumab + ipilimumab induction. He has a partial response. What is the maintenance strategy per the CheckMate 743 protocol?

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Correct answer: E — Continue nivolumab monotherapy maintenance every 4 weeks until progression (for up to 2 years)

In CheckMate 743, after induction with nivolumab + ipilimumab (4 cycles of ipilimumab), patients continue nivolumab monotherapy maintenance every 4 weeks until progression or for up to 2 years. Ipilimumab is only given during the induction phase. This mirrors the melanoma CheckMate 067 protocol structure. The nivolumab maintenance phase is where most of the sustained benefit is observed.

Reference: https://www.nice.org.uk/guidance/conditions-and-diseases/cancer