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T-DXd HER2-zero Gastric — SCE Medical Oncology MCQ

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HardGI CancersT-DXd HER2-zero GastricSCE Medical Oncology

A patient with HER2-positive unresectable gastric cancer asks whether NICE TA879 establishes routine NHS use of trastuzumab deruxtecan after trastuzumab. What is the accurate appraisal interpretation?

Educational content. Not a substitute for clinical judgement or local policy.

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Correct answer: CTA879 made no recommendation following absence of a company evidence submission

TA879 was terminated without a recommendation because the company did not submit evidence. That is different from a positive restricted recommendation or a clinical finding of no activity. A medicine’s licence or biologic plausibility does not by itself create a NICE-funded routine NHS indication.

Reference: NICE TA879: trastuzumab deruxtecan for HER2-positive advanced gastric cancer. https://www.nice.org.uk/guidance/ta879