HER2 Endometrial Cancer — SCE Medical Oncology MCQ
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Correct answer: C — Use pembrolizumab plus lenvatinib after progression on or after platinum treatment
TA904 recommends pembrolizumab plus lenvatinib for advanced or recurrent endometrial cancer that has progressed on or after platinum chemotherapy when curative surgery or radiotherapy is not possible. The recommendation is not monotherapy and does not mandate two extra regimens; a curative local option would take the patient outside the appraisal population.
Reference: NICE TA904: pembrolizumab with lenvatinib for advanced endometrial cancer. https://www.nice.org.uk/guidance/ta904/chapter/1-Recommendations