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Abiraterone Mechanism — SCE Medical Oncology MCQ

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HardUrological CancersAbiraterone MechanismSCE Medical Oncology

A man taking abiraterone plus prednisolone develops CTCAE grade 3 hypertension and grade 3 hypokalaemia. There is no arrhythmia. What is the most appropriate immediate treatment decision under the UK SmPC?

Educational content. Not a substitute for clinical judgement or local policy.

Reveal the answer and explanation

Correct answer: DWithhold abiraterone, correct the toxicities, and restart only after recovery to grade 1 or baseline

Explanation lettering: D = shown as A · A = shown as D

A is correct for grade 3 hypertension or hypokalaemia. B leaves dangerous hypokalaemia untreated; C is not the specified immediate strategy; D would remove ACTH suppression and may worsen mineralocorticoid excess; E ignores the grade-3 withholding threshold.

Reference: Abiraterone UK summary of product characteristics (Current UK SmPC, accessed August 2026): https://www.medicines.org.uk/emc/product/15402/smpc