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Desmoplastic Melanoma — SCE Medical Oncology MCQ

Instant feedback + full explanation. One question, done properly.

HardMelanoma & SkinDesmoplastic MelanomaSCE Medical Oncology

A patient with refractory metastatic colorectal cancer is responding to fruquintinib and is scheduled for elective abdominal surgery. What perioperative plan most closely matches the current UK SmPC?

Educational content. Not a substitute for clinical judgement or local policy.

Reveal the answer and explanation

Correct answer: E — Withhold fruquintinib for at least 14 days before surgery and 14 days afterwards, restarting once the incision has healed

Explanation lettering: B = shown as A · C = shown as B · A = shown as C

E is correct: VEGF-pathway inhibition can impair wound healing, and the Fruzaqla SmPC advises withholding treatment for at least 2 weeks before surgery and not resuming for at least 2 weeks afterwards, with adequate healing established. A, B and C all use shorter pre- and postoperative intervals than the product information specifies. D omits the required preoperative interruption even though its postoperative interval is closer to the recommendation.

Reference: Fruzaqla UK summary of product characteristics (Current UK SmPC, accessed 1 August 2026): https://www.medicines.org.uk/emc/product/16000/smpc