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Prostate Cancer nmCRPC — SCE Medical Oncology MCQ

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HardUrological CancersProstate Cancer nmCRPCSCE Medical Oncology

Pembrolizumab was previously withheld for grade 3 immune-mediated colitis and later restarted after complete resolution. The patient now develops a second grade 3 episode. What is the SmPC disposition?

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Correct answer: B — Permanently discontinue pembrolizumab after recurrent grade 3 colitis

Initial grade 2 or 3 colitis is withheld, but recurrent grade 3 or any grade 4 colitis requires permanent discontinuation. Pembrolizumab is not dose-reduced or schedule-shortened to manage immune toxicity. The recurrence is the decisive detail.

Reference: Keytruda UK SmPC. https://www.medicines.org.uk/emc/product/2498/smpc