Breast Cancer — SCE Medical Oncology MCQ

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ModerateBreast CancerBreast CancerSCE Medical Oncology

A 67-year-old woman on CDK4/6 inhibitor develops ALT 4× ULN with stable liver metastases on imaging. What should be suspected?

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Correct answer: A — CDK4/6 inhibitor-related hepatotoxicity

CDK4/6 inhibitor hepatotoxicity (most common with abemaciclib). Isolated transaminase rise without imaging progression suggests drug-related toxicity. Hold and dose reduce.

Reference: BNF CDK4/6 inhibitor monographs; ESMO 2024 MBC Guidelines