Six days after irinotecan, a patient develops afebrile watery diarrhoea without neutropenia or dehydration. Which initial loperamide instruction is

Question

Six days after irinotecan, a patient develops afebrile watery diarrhoea without neutropenia or dehydration. Which initial loperamide instruction is SmPC-concordant?

Accepted Answer

Take 4 mg, then 2 mg two-hourly; continue for 12 hours after the last liquid stool, maximum 48 hours

Answer

Take 2 mg twice daily from day 1 of each cycle, escalating after the first liquid stool

Answer

Take 4 mg initially, then 2 mg every 4 hours, stopping 24 hours after the final liquid stool

Answer

Take 4 mg initially, then 2 mg hourly, stopping when stool frequency falls below four episodes daily

Answer

Take 2 mg after each liquid stool, maximum 8 mg daily, continuing for 24 hours after the final stool

Bevacizumab Perforation — SCE Medical Oncology MCQ

Six days after irinotecan, a patient develops afebrile watery diarrhoea without neutropenia or dehydration. Which initial loperamide instruction is SmPC-concordant?