Olaparib is interrupted for grade 3 pancytopenia. Four weeks later the counts remain abnormal and transfusion support is still required. What is the

Question

Olaparib is interrupted for grade 3 pancytopenia. Four weeks later the counts remain abnormal and transfusion support is still required. What is the next investigation?

Accepted Answer

Arrange bone-marrow analysis and/or blood cytogenetic testing

Answer

Change immediately to niraparib without further investigation

Answer

Give prophylactic G-CSF and resume full-dose olaparib

Answer

Continue the interruption for 12 weeks before investigating

Answer

Restart olaparib at the lowest dose with weekly counts

Clear Cell Ovarian Cancer — SCE Medical Oncology MCQ

Olaparib is interrupted for grade 3 pancytopenia. Four weeks later the counts remain abnormal and transfusion support is still required. What is the next investigation?