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RCC — SCE Medical Oncology MCQ

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HardUrological CancersRCCSCE Medical Oncology

A patient receiving nivolumab plus ipilimumab develops grade 3 immune-mediated colitis. Infection has been excluded. What is the immediate management principle?

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Correct answer: B — Withhold immunotherapy and start guideline-directed corticosteroid treatment with specialist input

Grade 3 immune-mediated colitis requires immunotherapy interruption, prompt systemic corticosteroid treatment and oncology–gastroenterology input. Failure to improve triggers escalation to an appropriate biologic after infection assessment. The decision to resume PD-1 treatment is individual; severe toxicity generally precludes further CTLA-4 exposure.

Reference: https://www.nice.org.uk/guidance/conditions-and-diseases/cancer