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Ovarian Cancer — SCE Medical Oncology MCQ

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HardGynaecological CancersOvarian CancerSCE Medical Oncology

A carboplatin-containing regimen specifies target AUC 5. A radionuclide measurement gives GFR 52 mL/min. Using the Calvert formula in the UK product information, what carboplatin dose should be prescribed?

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Correct answer: A — 385 mg as the total carboplatin dose

The Calvert formula is total dose in mg = target AUC × (GFR + 25). Thus 5 × (52 + 25) = 5 × 77 = 385 mg. The result is not expressed per square metre. Subtracting 20%, omitting the non-renal 25 term or replacing the measured GFR with an arbitrary minimum would each produce an incorrect exposure.

Reference: Carboplatin 10 mg/mL UK summary of product characteristics (Current UK SmPC, accessed August 2026): https://www.medicines.org.uk/emc/product/3787/smpc