A patient with bone metastases is due to start denosumab 120 mg but still has an unhealed extraction socket after recent dental surgery. Calcium and

Question

A patient with bone metastases is due to start denosumab 120 mg but still has an unhealed extraction socket after recent dental surgery. Calcium and vitamin D are normal. What should the oncology team do?

Accepted Answer

Defer denosumab and confirm complete socket healing before the first dose

Answer

Substitute another denosumab brand because oral-surgery contraindications differ between formulations

Answer

Start denosumab after adding prophylactic metronidazole through the first treatment cycle

Answer

Give one loading dose of denosumab, then pause subsequent doses until the extraction socket heals

Answer

Start denosumab after confirming normal calcium and vitamin D despite the persistent unhealed socket

Li-Fraumeni Syndrome — SCE Medical Oncology MCQ

A patient with bone metastases is due to start denosumab 120 mg but still has an unhealed extraction socket after recent dental surgery. Calcium and vitamin D are normal. What should the oncology team do?